Edwin Encarnacion missed a second home run by an inch or two.
Tampa Bay's Evan Longoria hit a home run that had to stand up through a video review.
And the Toronto Blue Jays lost another one-run game Sunday.
"Very, very lucky," Rays manager Joe Maddon said after the Rays' 2-1, 10-inning victory.
"That's the way it goes sometimes," Blue Jays manager John Gibbons said.
Jose Lobaton hit a solo home run in the 10th inning to end it.
With one out, the Rays catcher sent a 2-1 pitch from Brad Lincoln (1-2) into the right-field seats.
Longoria put the Rays up 1-0 in the first with his 24th homer, an opposite-field drive to right that resulted in a 2:15 review by the umpires because a fan in the front row caught the ball just above the fence.
"They said it cleared it and the guy grabbed it beyond the fence," Gibbons said. "We thought maybe he had reached over."
It was not the only time Sunday that Gibbons would come out of the dugout to discuss whether a home run had been hit, but it was the only run given up by Toronto starter Todd Redmond.
"One bad pitch to Longoria," Redmond said. "He's one of the best hitting third basemen in the game right now.
"You do that, and you pay the price. I was hoping for that (replay reversal), and you never know. (The fan) probably reached over a little bit, but it was probably just far enough to where it didn't matter."
The Blue Jays tied it at 1 when Encarnacion connected for his 31st homer with two outs in the seventh. He nearly put Toronto ahead in the ninth, but his two-out drive off Fernando Rodney hit off the top of the left-field wall and the slugger wound up with a double.
Gibbons came out again, but this time there wasn't much to discuss.
"The second time I was begging," he said.
Encarnacion advanced to third on a wild pitch, but Adam Lind flew out and the Jays never got another man on base.
Jake McGee (3-3) struck out one during a perfect 10th.
Tampa Bay took two of three from Toronto, which hasn't won a series at Tropicana Field since April 2007.
Rays starter Chris Archer allowed one run and four hits over seven innings.
Redmond, a St. Petersburg native, gave up one run and six hits over six innings in his first start at Tampa Bay. It was the second straight strong start for the 28-year-old Redmond, who said he is doing nothing differently from what he did during nine years in the minor leagues.
"I'm staying with my strengths," he said. "The game is about timing, and right now I've got a good opportunity and I'm trying to take advantage of it."
Archer retired nine in a row before Anthony Gose started the fourth with a single. Gose stole second and went to third on Jose Bautista's one-out fly ball, but was left stranded when Encarnacion flied out.
Gose was the only Toronto base runner until Encarnacion's seventh-inning homer. After the home run, Adam Lind and Brett Lawrie had consecutive singles before Mark DeRosa grounded out.
It was the Blue Jays' seventh walkoff loss of the season and their eighth loss in extra innings.
"If you're going to play in prime time, you've got to win those games sooner or later," Gibbons said. "We've had so many of them over the course of the season and we haven't been able to win `em. That's the difference."
FOX 13 / WTVT-TV
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